Immunometabolism: new insights and lessons from antigen-directed cellular immune responses

• Published in: Seminars in immunopathology Vol. 42; no. 3; pp. 279 - 313
• Main Authors: Ramalho, Renata, Rao, Martin, Zhang, Chao, Agrati, Chiara, Ippolito, Giuseppe, Wang, Fu-Sheng, Zumla, Alimuddin, Maeurer, Markus
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2020; Springer Nature B.V
• Subjects: Antigens; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer therapies; Cell differentiation; Cells; Dietary supplements; Fatty acids; Gastrointestinal Microbiome; Humans; Immune response; Immune response (cell-mediated); Immunity (Disease); Immunity, Cellular; Immunology; Immunomodulation; Infections; Infectious diseases; Internal Medicine; Intestinal microflora; Lymphocytes; Metabolic Networks and Pathways; Metabolic pathways; Metabolism; Metabolites; Microbiota; Nutrients; Nutrition; Pathogens; Phosphorylation; Polyamines; Review; Tumor Microenvironment; Viral infections; Nutrition; T cell; Cytokine; Inflammation; Innate immune cell; Infection; Immunometabolism; Mitochondria; Tuberculosis; Immunotherapy; MTB; Cancer; Microbiome

Modulation of immune responses by nutrients is an important area of study in cellular biology and clinical sciences in the context of cancer therapies and anti-pathogen-directed immune responses in health and disease. We review metabolic pathways that influence immune cell function and cellular pers...