Distinct Properties of Long-Term Potentiation in the Dentate Gyrus along the Dorsoventral Axis: Influence of Age and Inhibition

• Published in: Scientific reports Vol. 7; no. 1; pp. 5157 - 10
• Main Authors: Schreurs, An, Sabanov, Victor, Balschun, Detlef
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.07.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 631/1647/1453/2205; 631/378/2591/2592; 64/60; 9/30; 9/74; Age; Dentate gyrus; Emotional behavior; Hippocampus; Humanities and Social Sciences; Inhibitory postsynaptic potentials; Learning; Long-term potentiation; multidisciplinary; Navigation behavior; Picrotoxin; Rodents; Science; Science (multidisciplinary); Spatial memory; Synaptic transmission; γ-Aminobutyric acid A receptors
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-05358-1

The hippocampus is important for spatial navigation, episodic memory and affective behaviour. Increasing evidence suggests that these multiple functions are accomplished by different segments along the dorsal-ventral (septal-temporal) axis. Long-term potentiation (LTP), the best-investigated cellula...