Utility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in HFE hemochromatosis

• Published in: Scientific reports Vol. 9; no. 1; pp. 20234 - 8
• Main Authors: Chin, Justin, Powell, Lawrie W., Ramm, Louise E., Ayonrinde, Oyekoya T., Ramm, Grant A., Olynyk, John K.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.12.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4020/4021/1607/1604; 692/4020/4021/1607/1605; Adult; Biopsy; Cirrhosis; Female; Ferritin; Ferritins - blood; Fibrosis; Genotype; Hemochromatosis; Hemochromatosis - diagnosis; Hemochromatosis - genetics; Hemochromatosis - metabolism; Hemochromatosis Protein - genetics; Hemochromatosis Protein - metabolism; Homozygote; Humanities and Social Sciences; Humans; Iron; Iron - metabolism; Iron Overload - diagnosis; Iron Overload - metabolism; Liver; Liver - metabolism; Liver cirrhosis; Liver Cirrhosis - diagnosis; Liver Cirrhosis - genetics; Liver Cirrhosis - metabolism; Male; Middle Aged; multidisciplinary; Mutation, Missense; Phlebotomy; Phlebotomy - methods; Retrospective Studies; ROC Curve; Science

Development of advanced hepatic fibrosis in HFE Hemochromatosis (HH) is influenced by hepatic iron concentration (HIC) and age. In patients with HH, it is important to assess the likelihood of cirrhosis and thus the need for confirmatory liver biopsy. Therapeutic phlebotomy also provides an estimate...