Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure
Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n=48), European adults (naïve travelers, n=22; expatriates with few pr...
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Published in | PloS one Vol. 8; no. 2; p. e55756 |
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Main Authors | , , , , , , , , , , , , , , , , , |
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Language | English |
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21.02.2013
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Abstract | Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n=48), European adults (naïve travelers, n=22; expatriates with few prior malaria exposures, n=15) and Mozambican adults with long-life malaria exposure (n=99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-1(42) (P=0.030) and a P. falciparum isolate (P=0.002), as well as higher IL-12 (P=0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-γ (P ≤ 0.0090), IL-2 (P ≤ 0.0379) and IL-8 (P ≤ 0.0233). Children also had higher IL-12 (P=0.0001), IL-4 (P=0.003), IL-1β (P=0.024) and TNF (P=0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A T(H)1/pro-inflammatory response was the hallmark of non-immune subjects. |
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AbstractList | Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n=48), European adults (naïve travelers, n=22; expatriates with few prior malaria exposures, n=15) and Mozambican adults with long-life malaria exposure (n=99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-1(42) (P=0.030) and a P. falciparum isolate (P=0.002), as well as higher IL-12 (P=0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-γ (P ≤ 0.0090), IL-2 (P ≤ 0.0379) and IL-8 (P ≤ 0.0233). Children also had higher IL-12 (P=0.0001), IL-4 (P=0.003), IL-1β (P=0.024) and TNF (P=0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A T(H)1/pro-inflammatory response was the hallmark of non-immune subjects. Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n = 48), European adults (naïve travelers, n = 22; expatriates with few prior malaria exposures, n = 15) and Mozambican adults with long-life malaria exposure (n = 99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-142 (P = 0.030) and a P. falciparum isolate (P = 0.002), as well as higher IL-12 (P = 0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-γ (P≤0.0090), IL-2 (P≤0.0379) and IL-8 (P≤0.0233). Children also had higher IL-12 (P = 0.0001), IL-4 (P = 0.003), IL-1β (P = 0.024) and TNF (P = 0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A TH1/pro-inflammatory response was the hallmark of non-immune subjects. Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n = 48), European adults (naïve travelers, n = 22; expatriates with few prior malaria exposures, n = 15) and Mozambican adults with long-life malaria exposure (n = 99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-1 42 ( P = 0.030) and a P. falciparum isolate ( P = 0.002), as well as higher IL-12 ( P = 0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-γ ( P≤ 0.0090), IL-2 ( P≤ 0.0379) and IL-8 ( P≤ 0.0233). Children also had higher IL-12 ( P = 0.0001), IL-4 ( P = 0.003), IL-1β ( P = 0.024) and TNF ( P = 0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A T H 1/pro-inflammatory response was the hallmark of non-immune subjects. |
Author | Guinovart, Caterina Angov, Evelina Pinazo, María-Jesús Moncunill, Gemma Nhabomba, Augusto Gascón, Joaquim Chitnis, Chetan E Dobaño, Carlota Jiménez, Alfons Mayor, Alfredo Bardají, Azucena Aguilar, Ruth Dutta, Sheetij Manaca, Maria N Barrios, Diana Muñoz, José Puyol, Laura Cisteró, Pau |
AuthorAffiliation | Burnet Institute, Australia 3 Walter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, United States of America 1 Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain 4 International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India 2 Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique |
AuthorAffiliation_xml | – name: 3 Walter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, United States of America – name: Burnet Institute, Australia – name: 2 Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique – name: 4 International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India – name: 1 Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain |
Author_xml | – sequence: 1 givenname: Gemma surname: Moncunill fullname: Moncunill, Gemma email: gemma.moncunil@cresib.cat organization: Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain. gemma.moncunil@cresib.cat – sequence: 2 givenname: Alfredo surname: Mayor fullname: Mayor, Alfredo – sequence: 3 givenname: Alfons surname: Jiménez fullname: Jiménez, Alfons – sequence: 4 givenname: Augusto surname: Nhabomba fullname: Nhabomba, Augusto – sequence: 5 givenname: Laura surname: Puyol fullname: Puyol, Laura – sequence: 6 givenname: Maria N surname: Manaca fullname: Manaca, Maria N – sequence: 7 givenname: Diana surname: Barrios fullname: Barrios, Diana – sequence: 8 givenname: Pau surname: Cisteró fullname: Cisteró, Pau – sequence: 9 givenname: Caterina surname: Guinovart fullname: Guinovart, Caterina – sequence: 10 givenname: Ruth surname: Aguilar fullname: Aguilar, Ruth – sequence: 11 givenname: Azucena surname: Bardají fullname: Bardají, Azucena – sequence: 12 givenname: María-Jesús surname: Pinazo fullname: Pinazo, María-Jesús – sequence: 13 givenname: Evelina surname: Angov fullname: Angov, Evelina – sequence: 14 givenname: Sheetij surname: Dutta fullname: Dutta, Sheetij – sequence: 15 givenname: Chetan E surname: Chitnis fullname: Chitnis, Chetan E – sequence: 16 givenname: José surname: Muñoz fullname: Muñoz, José – sequence: 17 givenname: Joaquim surname: Gascón fullname: Gascón, Joaquim – sequence: 18 givenname: Carlota surname: Dobaño fullname: Dobaño, Carlota |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23437061$$D View this record in MEDLINE/PubMed |
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Copyright | 2013 Moncunill et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. cc-by (c) Moncunill, Gemma et al., 2013 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/3.0/es 2013 Moncunill et al 2013 Moncunill et al |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The co-author AM is a PLOS ONE Editorial Board member. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. Produced the recombinant proteins: EA SD CEC. Designed and conducted the field trial: CG. Performed clinical diagnosis, management of malaria patients and collected clinical data: CG MJP JM JG AB. Coordinated data compilation and performed blood sample processing: RA LP DB PC MNM AN. Conceived and designed the experiments: CD JG AM GM. Performed the experiments: GM DB AJ. Analyzed the data: GM AM CD. Wrote the paper: GM AM CD. |
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Title | Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure |
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Volume | 8 |
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