Polymeric modification of gemcitabine via cyclic acetal linkage for enhanced anticancer potency with negligible side effects - Takemoto, Hiroyasu; Inaba, Takanori; Nomoto, Takahiro; Matsui, Makoto; Liu, Xiaomeng; Toyoda, Masahiro; Honda, Yuto; Taniwaki, Kaori; Yamada, Naoki; Kim, Junhyun; Tomoda, Keishiro; Nishiyama, Nobuhiro (Biomaterials, 2020)
Keywords: Acetals; Animals; antineoplastic agents; apoptosis; biocompatible materials; blood flow; cancer therapy; Cell Line, Tumor; Deoxycytidine - analogs & derivatives; Drug delivery system; gastrointestinal system; Gemcitabine; lysosomes; Mice; Pancreatic Neoplasms; pH-responsiveness; Polymers; Side effects; toxicity; Side effects; Gemcitabine; Polymers; Drug delivery system; pH-responsiveness