Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome - Wang, Li-Qiu; Liu, Tao; Yang, Shuai; Sun, Lin; Zhao, Zhi-Yao; Li, Li-Yue; She, Yuan-Chu; Zheng, Yan-Yan; Ye, Xiao-Yan; Bao, Qing; Dong, Guang-Hui; Li, Chun-Wei; et al. (Nature communications, 2021)
Keywords: 13/1; 13/106; 13/2; 13/21; 13/31; 13/89; 38/22; 49/90; 631/250/1933; 631/250/256/2177; 64/60; 692/420/256/2177; 692/499; 96/34; Alkanesulfonic Acids - poisoning; Animals; Apoptosis - drug effects; Apoptosis - genetics; Asthma; Asthma - chemically induced; Asthma - genetics; Asthma - metabolism; Calcium; Calcium ions; Caspase 1 - metabolism; Damage; Deoxyribonucleic acid; DNA; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Environmental Pollutants - poisoning; Female; Fluorocarbons - poisoning; Gene Expression - drug effects; Humanities and Social Sciences; IL-1β; Immune system; Immunity, Innate - drug effects; Immunity, Innate - genetics; Immunity, Innate - immunology; Inflammasomes; Inflammasomes - drug effects; Inflammasomes - genetics; Inflammasomes - metabolism; Inflammation; Inflammation - chemically induced; Inflammation - genetics; Inflammation - metabolism; Innate immunity; Kidneys; Macrophages - drug effects; Macrophages - metabolism; Manufacturing industry; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial DNA; multidisciplinary; NF-κB protein; Organs; Pattern recognition; Pattern recognition receptors; Perfluoro compounds; Perfluoroalkyl & polyfluoroalkyl substances; Perfluorooctane sulfonic acid; Pollutants; Pyroptosis; Receptors; Science; Science (multidisciplinary); Substrates; Sulfonates