KSHV RTA antagonizes SMC5/6 complex-induced viral chromatin compaction by hijacking the ubiquitin-proteasome system

• Published in: PLoS pathogens Vol. 18; no. 8; p. e1010744
• Main Authors: Han, Chunyan, Zhang, Dun, Gui, Chenwu, Huang, Liang, Chang, Sijia, Dong, Lianghui, Bai, Lei, Wu, Shuwen, Lan, Ke
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.08.2022; Public Library of Science (PLoS)
• Subjects: Analysis; Biology and Life Sciences; Cell cycle; Cell division; Cellular structure; Chromatin; Deoxyribonucleic acid; DNA; DNA repair; DNA viruses; Epigenetic inheritance; Epigenetics; Flow cytometry; Gene expression; Genes; Genomes; Hepatitis B; Herpesviruses; Histones; Host-virus relationships; Human papillomavirus; Identification and classification; Infections; Influence; Kaposi's sarcoma; Kaposis sarcoma; Latent infection; Maintenance; Medicine and Health Sciences; Proteasomes; Proteins; Replication; Research and Analysis Methods; Sarcoma; Structure; Ubiquitin; Viral infections; Viral proteins; Viruses; China

Kaposi’s sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus with the capacity to establish life-long latent infection. During latent infection, the viral genome persists as a circular episome that associates with cellular histones and exists as a nonintegrated minichromosome in the...