A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populations

• Published in: The Journal of clinical investigation Vol. 135; no. 1; pp. 1 - 19
• Main Authors: Cantoni, Claudia, Smirnov, Roman A., Firulyova, Maria, Andhey, Prabhakar S., Bradstreet, Tara R., Esaulova, Ekaterina, Terekhova, Marina, Schwarzkopf, Elizabeth A., Abdalla, Nada M., Kleverov, Maksim, Sabatino, Joseph J., Liu, Kang, Schwab, Nicholas, Meyer zu Hörste, Gerd, Cross, Anne H., Artyomov, Maxim N., Edelson, Brian T., Wu, Gregory F.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.01.2025
• Subjects: Adult; Aged; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - immunology; Alzheimer's disease; Autoimmune diseases; Central nervous system; Cerebrospinal fluid; COVID-19; COVID-19 - cerebrospinal fluid; COVID-19 - immunology; Datasets; Dendritic cells; Dendritic Cells - immunology; Diagnosis; Disease; Encephalitis; Female; Genetic aspects; Humans; Immune system; Immunologic diseases; Lymphocytes; Male; Microglia; Microglia - immunology; Middle Aged; Movement disorders; Multiple sclerosis; Multiple Sclerosis - cerebrospinal fluid; Multiple Sclerosis - immunology; Nervous system; Nervous system diseases; Neurodegenerative diseases; Neurological diseases; Parkinson Disease - cerebrospinal fluid; Parkinson Disease - genetics; Parkinson Disease - immunology; Parkinson's disease; Puncture; Risk factors; SARS-CoV-2 - immunology; Single-Cell Analysis; Spine; Transcriptome; Transcriptomics; United States; Innate immunity; Neuroscience; Adaptive immunity; Immunology; Neurological disorders

Single-cell transcriptomics applied to cerebrospinal fluid (CSF) for elucidating the pathophysiology of neurologic diseases has produced only a preliminary characterization of CSF immune cells. CSF derives from and borders central nervous system (CNS) tissue, allowing for comprehensive accounting of...