Clinicopathological and Prognostic Significance of Cancer Stem Cell Markers in Ovarian Cancer Patients: Evidence from 52 Studies

• Published in: Cellular physiology and biochemistry Vol. 46; no. 4; pp. 1716 - 1726
• Main Authors: Tao, Yifeng, Li, Hui, Huang, Rongyong, Mo, Dan, Zeng, Tian, Fang, Min, Li, Meiqin
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2018; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: AC133 Antigen - genetics; AC133 Antigen - metabolism; Aldh1; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; CD117; CD133; CD44; Chemotherapy; Databases, Factual; Dehydrogenases; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Gene expression; Gynecology; Humans; Hyaluronan Receptors - genetics; Hyaluronan Receptors - metabolism; Isoenzymes - genetics; Isoenzymes - metabolism; Kinases; Medical prognosis; Meta-analysis; Neoplastic Stem Cells - metabolism; Odds Ratio; Original Paper; Ovarian cancer; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - mortality; Ovarian Neoplasms - pathology; Prognosis; Proportional Hazards Models; Proteins; Proto-Oncogene Proteins c-kit - genetics; Proto-Oncogene Proteins c-kit - metabolism; Retinal Dehydrogenase - genetics; Retinal Dehydrogenase - metabolism; Signal transduction; Stem cells; Survival Rate; Tumors; CD117; Aldh1; CD44; CD133; Ovarian cancer; Meta-analysis

Background/Aims: Relevant markers of cancer stem cells (CSCs) may serve as commonly used biomarkers of ovarian cancer (OC). However, their actual clinicopathological and prognostic significance remains inconclusive. Thus, we conducted a meta-analysis to quantitatively evaluate the association betwee...