Maternally Derived Recombinant Human Anti-Hantavirus Monoclonal Antibodies Are Transferred to Mouse Offspring during Lactation and Neutralize Virus In Vitro

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Published inJournal of Virology Vol. 80; no. 8; pp. 4183 - 4186
Main Authors Yu, Shuyang, Liang, Mifang, Fan, BaoLiang, Xu, Hongtao, Li, Chuan, Zhang, Quanfu, Li, Dexin, Tang, Bo, Li, Shijie, Dai, Yunping, Wang, Meili, Zheng, Min, Yan, Bingxue, Zhu, Qinghong, Li, Ning
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.04.2006
Subjects
Animals
Antibodies, Monoclonal - biosynthesis
Antibodies, Monoclonal - immunology
Antibodies, Viral - biosynthesis
Biological and medical sciences
Female
Fluorescent Antibody Technique
Fundamental and applied biological sciences. Psychology
Hantavirus
Hantavirus - immunology
Immunity, Maternally-Acquired
Lactation
Mice
Mice, Transgenic
Microbiology
Milk - immunology
Miscellaneous
Pathogenesis and Immunity
Recombinant Proteins - biosynthesis
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Virology
Virus
Human
Vertebrata
Mammalia
Bunyaviridae
Lactation
Microbiology
Mouse
Rodentia
Monoclonal antibody
Hantavirus
Virology
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Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList Transgenic mice expressing a recombinant human monoclonal antibody (rHMAb) against hantavirus were generated. These mice could be used as models to explore the possibilities of producing rHMAbs for therapeutic purposes. The highest concentration of the rHMAb in the milk of the transgenic females was 6.6 mg/ml. The rHMAb was also detected in the sera of pups fed by the transgenic females. Both the rHMAbs in the milk of transgenic mice and those in the sera of suckling pups were found to be active against hantaviruses, although the light chain of the antibody absorbed by the pups was modified by N-linked glycosylation.
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
Transgenic mice expressing a recombinant human monoclonal antibody (rHMAb) against hantavirus were generated. These mice could be used as models to explore the possibilities of producing rHMAbs for therapeutic purposes. The highest concentration of the rHMAb in the milk of the transgenic females was 6.6 mg/ml. The rHMAb was also detected in the sera of pups fed by the transgenic females. Both the rHMAbs in the milk of transgenic mice and those in the sera of suckling pups were found to be active against hantaviruses, although the light chain of the antibody absorbed by the pups was modified by N-linked glycosylation.Transgenic mice expressing a recombinant human monoclonal antibody (rHMAb) against hantavirus were generated. These mice could be used as models to explore the possibilities of producing rHMAbs for therapeutic purposes. The highest concentration of the rHMAb in the milk of the transgenic females was 6.6 mg/ml. The rHMAb was also detected in the sera of pups fed by the transgenic females. Both the rHMAbs in the milk of transgenic mice and those in the sera of suckling pups were found to be active against hantaviruses, although the light chain of the antibody absorbed by the pups was modified by N-linked glycosylation.
Author Shuyang Yu
Qinghong Zhu
Dexin Li
BaoLiang Fan
Mifang Liang
Bingxue Yan
Chuan Li
Hongtao Xu
Quanfu Zhang
Yunping Dai
Bo Tang
Ning Li
Meili Wang
Shijie Li
Min Zheng
AuthorAffiliation State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100094, 1 State Key Laboratory for Infectious Diseases Control and Prevention, China CDC, Beijing 100052, 2 Animal Science and Technology College of He Bei Agricultural University, Baoding 071001, People'sRepublic of China 3
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Keywords Virus
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Vertebrata
Mammalia
Bunyaviridae
Lactation
Microbiology
Mouse
Rodentia
Monoclonal antibody
Hantavirus
Virology
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Corresponding author. Mailing address: State Key Lab For Agrobiotechnology, Yuanmingyuan Western Road 2#, Beijing 100094, People's Republic of China. Phone: 86 10 6273 3323. Fax: 86 10 6273 3904. E-mail: ninglbau@public3.bta.net.cn.
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Transgenic mice expressing a recombinant human monoclonal antibody (rHMAb) against hantavirus were generated. These mice could be used as models to explore the...
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StartPage 4183
SubjectTerms Animals
Antibodies, Monoclonal - biosynthesis
Antibodies, Monoclonal - immunology
Antibodies, Viral - biosynthesis
Biological and medical sciences
Female
Fluorescent Antibody Technique
Fundamental and applied biological sciences. Psychology
Hantavirus
Hantavirus - immunology
Immunity, Maternally-Acquired
Lactation
Mice
Mice, Transgenic
Microbiology
Milk - immunology
Miscellaneous
Pathogenesis and Immunity
Recombinant Proteins - biosynthesis
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Virology
Title Maternally Derived Recombinant Human Anti-Hantavirus Monoclonal Antibodies Are Transferred to Mouse Offspring during Lactation and Neutralize Virus In Vitro
URI http://jvi.asm.org/content/80/8/4183.abstract
https://www.ncbi.nlm.nih.gov/pubmed/16571835
https://www.proquest.com/docview/17119880
https://www.proquest.com/docview/67814841
https://pubmed.ncbi.nlm.nih.gov/PMC1440470
Volume 80
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