Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models - Tosh, Justin L.; Rhymes, Elena R.; Mumford, Paige; Whittaker, Heather T.; Pulford, Laura J.; Noy, Sue J.; Cleverley, Karen; Walker, Matthew C.; Tybulewicz, Victor L. J.; Wykes, Rob C.; Fisher, Elizabeth M. C.; Wiseman, Frances K. (Scientific reports, 2021)
Keywords: 631/208/207; 631/208/2490; 631/208/366; 631/378; 631/378/1689; 631/378/2583; 692/617/375/365; Age; Alzheimer Disease - complications; Alzheimer Disease - genetics; Alzheimer's disease; Amyloid beta-Peptides - chemistry; Amyloid beta-Peptides - genetics; Amyloid beta-Protein Precursor - genetics; Amyloid precursor protein; Animal models; Animals; Brain - pathology; Chromosome 21; Chromosomes; Chromosomes, Mammalian - genetics; Disease Models, Animal; Down syndrome; Down Syndrome - complications; Down Syndrome - genetics; Down's syndrome; Genes; Humanities and Social Sciences; Mice; Mice, Transgenic; multidisciplinary; Neurodegenerative diseases; Phenotype; Phosphotransferases - metabolism; Protein Aggregates; Protein-Arginine N-Methyltransferases - metabolism; Science; Science (multidisciplinary); Segmental Duplications, Genomic; Seizures - complications; Seizures - pathology; Solubility; Survival Analysis; Transgenes; Trisomy