Lactate promoted cisplatin resistance in NSCLC by modulating the m6A modification-mediated FOXO3/MAGI1-IT1/miR-664b-3p/IL-6R axis - Bo, Wei; Yu, Ning; Wang, Xiaokai; Wang, Chun; Liu, Chunying (Neoplasia (New York, N.Y.), 2024)
Keywords: Adaptor Proteins, Signal Transducing; Adenine - analogs & derivatives; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - genetics; Cell Adhesion Molecules; Cell Line, Tumor; Cell Proliferation; Cisplatin - pharmacology; Cisplatin resistance; Drug Resistance, Neoplasm - genetics; Forkhead Box Protein O3; FOXO3; Guanylate Kinases; Humans; Lactate; Lactic Acid; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; MAGI1-IT1; MicroRNAs - genetics; NSCLC; Original Research; Transcription Factors; ceRNA; MAGI1-IT1; YTHDF2; PCNA; NSCLC; Lactate; IHC; LncRNAs; qRT-PCR; MeRIP-PCR; FOXO3; FOXOs; ChIP; DDP; TUNEL; shRNA; IC50; EdU; RIP; m6A; CCK-8; Cisplatin resistance; IL6R