Hericium erinaceus mycelium and its small bioactive compounds promote oligodendrocyte maturation with an increase in myelin basic protein

• Published in: Scientific reports Vol. 11; no. 1; pp. 6551 - 13
• Main Authors: Huang, Hui-Ting, Ho, Chia-Hsin, Sung, Hsin-Yu, Lee, Li-Ya, Chen, Wan-Ping, Chen, Yu-Wen, Chen, Chin-Chu, Yang, Chung-Shi, Tzeng, Shun-Fen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/2596; 692/700/2814; Action potential; Axons; Bioactive compounds; Brain slice preparation; Central nervous system; Cerebellum; Corpus callosum; Diterpenes; Fibers; Gene expression; Glial stem cells; Humanities and Social Sciences; Immunoreactivity; Isoprene; Maturation; multidisciplinary; Myelin basic protein; Myelination; Neonates; Nervous system; Neurodevelopmental disorders; Neurological diseases; Neuroprotection; Oligodendrocytes; Oral administration; Proteins; Science; Science (multidisciplinary); Transgenic animals

Oligodendrocytes (OLs), myelin-producing glia in the central nervous system (CNS), produce a myelin extension that enwraps axons to facilitate action potential propagation. An effective approach to induce oligodendrogenesis and myelination is important to foster CNS development and promote myelin re...