Specificity models in MAPK cascade signaling

The precise execution of various cellular functions relies on the maintenance of signaling specificity from input detection to cellular outputs. However, diverse signaling pathways share similar or identical intermediate components. A well‐conserved intermediate, the Mitogen‐Activated Protein Kinase...

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Published inFEBS open bio Vol. 13; no. 7; pp. 1177 - 1192
Main Authors Ma, Yan, Nicolet, Jade
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.07.2023
John Wiley and Sons Inc
Wiley
Subjects
Animals
Flowers & plants
Intermediates
Kinases
Ligands
MAP kinase
MAP Kinase Signaling System - physiology
MAPK cascade
MAPK Signalling
mitogen-activated protein kinase
Mitogen-Activated Protein Kinases - metabolism
Phosphorylation
plant signaling
Proteins
Review
Reviews
RLK receptors
Saccharomyces cerevisiae - metabolism
Signal Transduction
signaling specificity
yeasts
signaling specificity
MAPK cascade
RLK receptors
plant signaling
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Abstract The precise execution of various cellular functions relies on the maintenance of signaling specificity from input detection to cellular outputs. However, diverse signaling pathways share similar or identical intermediate components. A well‐conserved intermediate, the Mitogen‐Activated Protein Kinase (MAPK) cascade, participates in a myriad of signaling pathways, regulating signal transduction from input to output. This typifies the “hourglass conundrum”, where a multitude of inputs and outputs all operate through a limited number of common intermediates. Therefore, understanding how MAPK cascades regulate a variety of outputs with specificity is a fundamental question in biology. This review highlights four major insulating mechanisms that improve signaling specificity: selective activation, compartmentalization, combinatorial signaling, and cross‐pathway inhibition. We focus on plant pathways that share MAPK cascade components and compare mechanisms with those of animals and yeast. We hope this conceptual overview will aid future studies to better understand plant signaling specificity. Diverse signaling pathways share similar or identical intermediate components. The MAPK cascade is a well‐conserved intermediate, participating in myriad signaling pathways. The precise execution of various cellular functions relies on signaling specificity from input detection to cellular outputs. Comparing plant and animal pathways, this review highlights four major insulating mechanisms that improve signaling specificity.
AbstractList The precise execution of various cellular functions relies on the maintenance of signaling specificity from input detection to cellular outputs. However, diverse signaling pathways share similar or identical intermediate components. A well-conserved intermediate, the Mitogen-Activated Protein Kinase (MAPK) cascade, participates in a myriad of signaling pathways, regulating signal transduction from input to output. This typifies the "hourglass conundrum", where a multitude of inputs and outputs all operate through a limited number of common intermediates. Therefore, understanding how MAPK cascades regulate a variety of outputs with specificity is a fundamental question in biology. This review highlights four major insulating mechanisms that improve signaling specificity: selective activation, compartmentalization, combinatorial signaling, and cross-pathway inhibition. We focus on plant pathways that share MAPK cascade components and compare mechanisms with those of animals and yeast. We hope this conceptual overview will aid future studies to better understand plant signaling specificity.
The precise execution of various cellular functions relies on the maintenance of signaling specificity from input detection to cellular outputs. However, diverse signaling pathways share similar or identical intermediate components. A well‐conserved intermediate, the Mitogen‐Activated Protein Kinase (MAPK) cascade, participates in a myriad of signaling pathways, regulating signal transduction from input to output. This typifies the “hourglass conundrum”, where a multitude of inputs and outputs all operate through a limited number of common intermediates. Therefore, understanding how MAPK cascades regulate a variety of outputs with specificity is a fundamental question in biology. This review highlights four major insulating mechanisms that improve signaling specificity: selective activation, compartmentalization, combinatorial signaling, and cross‐pathway inhibition. We focus on plant pathways that share MAPK cascade components and compare mechanisms with those of animals and yeast. We hope this conceptual overview will aid future studies to better understand plant signaling specificity. Diverse signaling pathways share similar or identical intermediate components. The MAPK cascade is a well‐conserved intermediate, participating in myriad signaling pathways. The precise execution of various cellular functions relies on signaling specificity from input detection to cellular outputs. Comparing plant and animal pathways, this review highlights four major insulating mechanisms that improve signaling specificity.
The precise execution of various cellular functions relies on the maintenance of signaling specificity from input detection to cellular outputs. However, diverse signaling pathways share similar or identical intermediate components. A well-conserved intermediate, the Mitogen-Activated Protein Kinase (MAPK) cascade, participates in a myriad of signaling pathways, regulating signal transduction from input to output. This typifies the "hourglass conundrum", where a multitude of inputs and outputs all operate through a limited number of common intermediates. Therefore, understanding how MAPK cascades regulate a variety of outputs with specificity is a fundamental question in biology. This review highlights four major insulating mechanisms that improve signaling specificity: selective activation, compartmentalization, combinatorial signaling, and cross-pathway inhibition. We focus on plant pathways that share MAPK cascade components and compare mechanisms with those of animals and yeast. We hope this conceptual overview will aid future studies to better understand plant signaling specificity.The precise execution of various cellular functions relies on the maintenance of signaling specificity from input detection to cellular outputs. However, diverse signaling pathways share similar or identical intermediate components. A well-conserved intermediate, the Mitogen-Activated Protein Kinase (MAPK) cascade, participates in a myriad of signaling pathways, regulating signal transduction from input to output. This typifies the "hourglass conundrum", where a multitude of inputs and outputs all operate through a limited number of common intermediates. Therefore, understanding how MAPK cascades regulate a variety of outputs with specificity is a fundamental question in biology. This review highlights four major insulating mechanisms that improve signaling specificity: selective activation, compartmentalization, combinatorial signaling, and cross-pathway inhibition. We focus on plant pathways that share MAPK cascade components and compare mechanisms with those of animals and yeast. We hope this conceptual overview will aid future studies to better understand plant signaling specificity.
Author Nicolet, Jade
Ma, Yan
AuthorAffiliation 1 Department of Plant Molecular Biology, Biophore, UNIL‐Sorge University of Lausanne Switzerland
AuthorAffiliation_xml – name: 1 Department of Plant Molecular Biology, Biophore, UNIL‐Sorge University of Lausanne Switzerland
Author_xml – sequence: 1
  givenname: Yan
  orcidid: 0000-0003-3663-9060
  surname: Ma
  fullname: Ma, Yan
  email: yan.ma@unil.ch
  organization: University of Lausanne
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  givenname: Jade
  orcidid: 0000-0002-9007-7719
  surname: Nicolet
  fullname: Nicolet, Jade
  organization: University of Lausanne
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37157227$$D View this record in MEDLINE/PubMed
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Issue 7
Keywords signaling specificity
MAPK cascade
RLK receptors
plant signaling
Language English
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Snippet The precise execution of various cellular functions relies on the maintenance of signaling specificity from input detection to cellular outputs. However,...
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SubjectTerms Animals
Flowers & plants
Intermediates
Kinases
Ligands
MAP kinase
MAP Kinase Signaling System - physiology
MAPK cascade
MAPK Signalling
mitogen-activated protein kinase
Mitogen-Activated Protein Kinases - metabolism
Phosphorylation
plant signaling
Proteins
Review
Reviews
RLK receptors
Saccharomyces cerevisiae - metabolism
Signal Transduction
signaling specificity
yeasts
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Title Specificity models in MAPK cascade signaling
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Volume 13
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