Alpha‐synuclein pathology in the olfactory pathways of dementia patients

• Published in: Journal of anatomy Vol. 211; no. 1; pp. 117 - 124
• Main Authors: Hubbard, Paul S., Esiri, Margaret M., Reading, Margaret, McShane, Rupert, Nagy, Zsuzsanna
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2007; Blackwell Science Inc
• Subjects: Aged; alpha-Synuclein - analysis; alpha‐synuclein; Alzheimer's disease; Amygdala - chemistry; Dementia - diagnosis; Dementia - metabolism; dementia with Lewy dodies; Hippocampus - chemistry; Humans; Immunohistochemistry; Lewy Bodies - chemistry; Lewy Body Disease - diagnosis; Lewy pathology; Neurodegenerative Diseases - complications; Neurodegenerative Diseases - diagnosis; Odds Ratio; Olfaction Disorders - etiology; Olfaction Disorders - metabolism; Olfactory Bulb - chemistry; Olfactory Pathways - chemistry; Original; Parkinson Disease - diagnosis; Parkinson's disease
• ISSN: 0021-8782; 1469-7580
• DOI: 10.1111/j.1469-7580.2007.00748.x

Lewy‐type pathology is a characteristic of a number of neurodegenerative disorders, including Parkinson's disease and dementia with Lewy bodies. Thus far, the definitive diagnosis of these dementias can only be confirmed at post‐mortem. However, it is known that the loss of smell (anosmia) is a...