Rare variants in TMEM132D in a case-control sample for panic disorder

• Published in: American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 159B; no. 8; pp. 896 - 907
• Main Authors: Quast, Carina, Altmann, Andre, Weber, Peter, Arloth, Janine, Bader, Daniel, Heck, Angela, Pfister, Hildegard, Müller-Myhsok, Bertram, Erhardt, Angelika, Binder, Elisabeth B.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2012; Wiley-Liss; Wiley Subscription Services, Inc
• Subjects: Adult and adolescent clinical studies; Agoraphobia - genetics; anxiety disorder; Anxiety disorders. Neuroses; Biological and medical sciences; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genetics; Genome-Wide Association Study; Genotype; High-Throughput Nucleotide Sequencing; Humans; Male; Medical genetics; Medical sciences; Membrane Proteins - genetics; next-generation sequencing; Panic disorder; Panic Disorder - genetics; Phobic Disorders - genetics; Polymorphism, Single Nucleotide; pooled DNA; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; rare variants; Sequence Analysis, DNA; SOLiD; rare variants; Panic; Nucleotide sequence; next-generation sequencing; Sample; Anxiety disorder; Check; pooled DNA; Case study; Variant; DNA; Pool; Sequencing; SOLiD

Genome‐wide association studies have identified common variants associated with common diseases. Most variants, however, explain only a small proportion of the estimated heritability, suggesting that rare variants might contribute to a larger extent to common diseases than assumed to date. Here, we...