Co‐administration of proton pump inhibitors delays elimination of plasma methotrexate in high‐dose methotrexate therapy - Suzuki, Kunihiro; Doki, Kosuke; Homma, Masato; Tamaki, Hirofumi; Hori, Satoko; Ohtani, Hisakazu; Sawada, Yasufumi; Kohda, Yukinao (British journal of clinical pharmacology, 2009)
Keywords: ABCG2; Adolescent; Adult; Aged; Antimetabolites, Antineoplastic - administration & dosage; Antimetabolites, Antineoplastic - metabolism; ATP Binding Cassette Transporter, Sub-Family G, Member 2; ATP-Binding Cassette Transporters - metabolism; Biological and medical sciences; Biological Transport - drug effects; breast cancer resistance protein; delayed elimination; Drug Interactions; Female; Humans; Logistic Models; Male; Medical sciences; methotrexate; Methotrexate - administration & dosage; Methotrexate - metabolism; Middle Aged; multiple logistic regression analysis; Neoplasm Proteins - metabolism; Neoplasms - drug therapy; Neoplasms - metabolism; Pharmacology. Drug treatments; proton pump inhibitors; Proton Pump Inhibitors - pharmacokinetics; Proton Pump Inhibitors - pharmacology; Young Adult; Antineoplastic agent; Biological fluid; Treatment resistance; Elimination; Regression analysis; Breast cancer resistance protein; Proton pump inhibitor; Blood plasma; Antifolate; Logistic regression; ABCG2 gene; proton pump inhibitors; Treatment; Antimetabolic; multiple logistic regression analysis; delayed elimination; Methotrexate; High dose; ABC transporter; ABCG2