TP53 Mutations in Human Cancer: Database Reassessment and Prospects for the Next Decade

• Published in: Human mutation Vol. 35; no. 6; pp. 672 - 688
• Main Authors: Leroy, Bernard, Anderson, Martha, Soussi, Thierry
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.06.2014; John Wiley & Sons, Inc
• Subjects: cancer; Databases, Genetic; DNA Mutational Analysis; Germ-Line Mutation; Humans; LSDB; Mutation; Neoplasms - genetics; Neoplasms - pathology; TP53; Tumor Suppressor Protein p53 - genetics; mutation; cancer; TP53; LSDB

ABSTRACT More than 50% of human tumors carry TP53 gene mutations and in consequence more than 45,000 somatic and germline mutations have been gathered in the UMD TP53 database (http://p53.fr). Analyses of these mutations have been invaluable for bettering our knowledge on the structure–function rela...