The gut microbiome-joint connection: implications in osteoarthritis

Osteoarthritis is a debilitating disease leading to joint degeneration, inflammation, pain, and disability. Despite efforts to develop a disease modifying treatment, the only accepted and available clinical approaches involve palliation. Although many factors contribute to the development of osteoar...

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Published inCurrent opinion in rheumatology Vol. 32; no. 1; p. 92
Main Authors Favazzo, Lacey J, Hendesi, Honey, Villani, David A, Soniwala, Sarah, Dar, Qurratul-Ain, Schott, Eric M, Gill, Steven R, Zuscik, Michael J
Format Journal Article
LanguageEnglish
Published United States 01.01.2020
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Abstract Osteoarthritis is a debilitating disease leading to joint degeneration, inflammation, pain, and disability. Despite efforts to develop a disease modifying treatment, the only accepted and available clinical approaches involve palliation. Although many factors contribute to the development of osteoarthritis, the gut microbiome has recently emerged as an important pathogenic factor in osteoarthritis initiation and progression. This review examines the literature to date regarding the link between the gut microbiome and osteoarthritis. Studies showing correlations between serum levels of bacterial metabolites and joint degeneration were the first links connecting a dysbiosis of the gut microbiome with osteoarthritis. Further investigations have demonstrated that microbial community shifts induced by antibiotics, a germ-free environment or high-fat are important underlying factors in joint homeostasis and osteoarthritis. It follows that strategies to manipulate the microbiome have demonstrated efficacy in mitigating joint degeneration in osteoarthritis. Moreover, we have observed that dietary supplementation with nutraceuticals that are joint protective may exert their influence via shifts in the gut microbiome. Although role of the microbiome in osteoarthritis is an area of intense study, no clear mechanism of action has been determined. Increased understanding of how the two factors interact may provide mechanistic insight into osteoarthritis and lead to disease modifying treatments.
AbstractList Osteoarthritis is a debilitating disease leading to joint degeneration, inflammation, pain, and disability. Despite efforts to develop a disease modifying treatment, the only accepted and available clinical approaches involve palliation. Although many factors contribute to the development of osteoarthritis, the gut microbiome has recently emerged as an important pathogenic factor in osteoarthritis initiation and progression. This review examines the literature to date regarding the link between the gut microbiome and osteoarthritis. Studies showing correlations between serum levels of bacterial metabolites and joint degeneration were the first links connecting a dysbiosis of the gut microbiome with osteoarthritis. Further investigations have demonstrated that microbial community shifts induced by antibiotics, a germ-free environment or high-fat are important underlying factors in joint homeostasis and osteoarthritis. It follows that strategies to manipulate the microbiome have demonstrated efficacy in mitigating joint degeneration in osteoarthritis. Moreover, we have observed that dietary supplementation with nutraceuticals that are joint protective may exert their influence via shifts in the gut microbiome. Although role of the microbiome in osteoarthritis is an area of intense study, no clear mechanism of action has been determined. Increased understanding of how the two factors interact may provide mechanistic insight into osteoarthritis and lead to disease modifying treatments.
Author Favazzo, Lacey J
Dar, Qurratul-Ain
Gill, Steven R
Soniwala, Sarah
Hendesi, Honey
Villani, David A
Zuscik, Michael J
Schott, Eric M
Author_xml – sequence: 1
  givenname: Lacey J
  surname: Favazzo
  fullname: Favazzo, Lacey J
  organization: Department of Orthopedics, Anschutz Medical Campus
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  givenname: Honey
  surname: Hendesi
  fullname: Hendesi, Honey
  organization: Department of Orthopedics, Anschutz Medical Campus
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  givenname: David A
  surname: Villani
  fullname: Villani, David A
  organization: Cell Biology, Stems Cells and Development Program, Anschutz Medical Campus, University of Colorado, Aurora, Colorado
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  givenname: Sarah
  surname: Soniwala
  fullname: Soniwala, Sarah
  organization: Department of Biology, University of Rochester, Rochester, New York
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  givenname: Qurratul-Ain
  surname: Dar
  fullname: Dar, Qurratul-Ain
  organization: Department of Biology, University of Rochester, Rochester, New York
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  surname: Schott
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  organization: Solarea Bio, Cambridge, Massachusetts
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  surname: Gill
  fullname: Gill, Steven R
  organization: Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
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  givenname: Michael J
  surname: Zuscik
  fullname: Zuscik, Michael J
  organization: Center for Musculoskeletal Research, University of Rochester Medical Center
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Snippet Osteoarthritis is a debilitating disease leading to joint degeneration, inflammation, pain, and disability. Despite efforts to develop a disease modifying...
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StartPage 92
SubjectTerms Dysbiosis - complications
Dysbiosis - metabolism
Dysbiosis - microbiology
Gastrointestinal Microbiome - physiology
Humans
Inflammation - metabolism
Inflammation - microbiology
Osteoarthritis - metabolism
Osteoarthritis - microbiology
Title The gut microbiome-joint connection: implications in osteoarthritis
URI https://www.ncbi.nlm.nih.gov/pubmed/31724973
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