tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel

• Published in: Brain stimulation Vol. 15; no. 5; pp. 1153 - 1162
• Main Authors: Nandi, Tulika, Puonti, Oula, Clarke, William T., Nettekoven, Caroline, Barron, Helen C., Kolasinski, James, Hanayik, Taylor, Hinson, Emily L., Berrington, Adam, Bachtiar, Velicia, Johnstone, Ainslie, Winkler, Anderson M., Thielscher, Axel, Johansen-Berg, Heidi, Stagg, Charlotte J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2022; Elsevier
• Subjects: Brain - diagnostic imaging; electric field; GABA; gamma-Aminobutyric Acid; Gray Matter - diagnostic imaging; Inter-individual variability; Modelling; Motor Cortex - diagnostic imaging; Motor Cortex - physiology; MRS; tDCS; Transcranial Direct Current Stimulation - methods; GABA; electric field; Modelling; tDCS; Inter-individual variability; MRS

Transcranial direct current stimulation (tDCS) has wide ranging applications in neuro-behavioural and physiological research, and in neurological rehabilitation. However, it is currently limited by substantial inter-subject variability in responses, which may be explained, at least in part, by anato...