Fatal suppurative meningoencephalitis caused by Klebsiella pneumoniae in two calves

One calf died (No. 1) and another was euthanized following astasia (No. 2). Histopathological examination revealed suppurative meningoencephalitis in these calves. Klebsiella pneumoniae antigens were detected in lesions. Thymocytes were decreased in the thymus cortex in both cases. 16S rRNA gene seq...

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Published inJournal of Veterinary Medical Science Vol. 83; no. 7; pp. 1113 - 1119
Main Authors KOMATSU, Tetsuya, YOSHIDA, Erina, SHIGENAGA, Ayumi, YASUIE, Nozomi, UCHIYAMA, Shintaro, TAKAMURA, Yuji, SUGIE, Kennosuke, KIMURA, Kumiko, HARITANI, Makoto, SHIBAHARA, Tomoyuki
Format Journal Article
LanguageEnglish
Published JAPANESE SOCIETY OF VETERINARY SCIENCE 2021
The Japanese Society of Veterinary Science
Subjects
cattle
Klebsiella pneumoniae
meningoencephalitis
multidrug resistance
Pathology
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Summary:One calf died (No. 1) and another was euthanized following astasia (No. 2). Histopathological examination revealed suppurative meningoencephalitis in these calves. Klebsiella pneumoniae antigens were detected in lesions. Thymocytes were decreased in the thymus cortex in both cases. 16S rRNA gene sequencing of the No. 1 isolate and bacterial extracts from formalin fixed paraffin embedded sections of No. 2 revealed that both samples were K. pneumoniae. The No. 1 isolate showed multidrug resistance against penicillin antibiotics, fosfomycin, streptomycin, macrolide antibiotics, tetracycline antibiotics, and clindamycin. Immunosuppression is a significant septicemic K. pneumoniae infection risk factor. Our study provides new aspects regarding K. pneumoniae infections in cattle, bacterial meningoencephalitis differentiation, and K. pneumoniae and bacterial meningoencephalitis treatments.
Bibliography:These authors contributed equally to this work.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.21-0166