Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation

• Published in: Trends in genetics Vol. 38; no. 2; pp. 182 - 193
• Main Authors: Kan, Ryan L., Chen, Jianjun, Sallam, Tamer
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2022
• Subjects: Animals; DNA Methylation; Epigenesis, Genetic; epigenetics; Gene Expression Regulation - genetics; gene regulation; Histones - genetics; Histones - metabolism; Methylation; RNA methylation; RNA modification; RNA, Long Noncoding - metabolism; RNA modification; gene regulation; epigenetics; RNA methylation
• ISSN: 0168-9525
• DOI: 10.1016/j.tig.2021.06.014

Epigenetic modifications occur on genomic DNA and histones to influence gene expression. More recently, the discovery that mRNA undergoes similar chemical modifications that powerfully impact transcript turnover and translation adds another layer of dynamic gene regulation. Central to precise and sy...