Genetic architecture of Alzheimer's disease

• Published in: Neurobiology of disease Vol. 143; p. 104976
• Main Authors: Neuner, Sarah M., TCW, Julia, Goate, Alison M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2020; Elsevier

Advances in genetic and genomic technologies over the last thirty years have greatly enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD). Several genes including APP, PSEN1, PSEN2, and APOE have been shown to exhibit large effects on disease susceptibility, wi...