Systemic Antibiotics and Chlorhexidine Associated with Periodontal Therapy: Microbiological Effect on Intraoral Surfaces and Saliva

The effect of systemic antibiotics on the microbial profile of extracrevicular sites after periodontal treatment is currently the subject of research. This study evaluated the microbiological effects on different oral cavity sites of scaling and root planing (SRP) combined with antimicrobial chemica...

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Published inAntibiotics (Basel) Vol. 12; no. 5; p. 847
Main Authors Mendes, Stella de Noronha Campos, Esteves, Camila Machado, Mendes, Juliana Alethusa Velloso, Feres, Magda, Figueiredo, Nathalia, de Miranda, Tamires Szeremeske, Shibli, Jamil Awad, Figueiredo, Luciene Cristina
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 04.05.2023
MDPI
Subjects
Amoxicillin
Analysis
antibacterial agents
Antibiotics
Antiinfectives and antibacterials
Bacteria
Biofilms
Chemical control
Chlorhexidine
Deoxyribonucleic acid
DNA
Hybridization
Metronidazole
Microbiology
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Mouth
Oral cavity
Pathogens
periodontal diseases
Periodontitis
Planing
Saliva
Tongue
Brazil
saliva
tongue
antibacterial agents
metronidazole
periodontal diseases
antibiotics
biofilms
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Abstract The effect of systemic antibiotics on the microbial profile of extracrevicular sites after periodontal treatment is currently the subject of research. This study evaluated the microbiological effects on different oral cavity sites of scaling and root planing (SRP) combined with antimicrobial chemical control in the treatment of periodontitis. Sixty subjects were randomly assigned to receive SRP alone or combined with metronidazole (MTZ) + amoxicillin (AMX) for 14 days, with or without chlorhexidine mouth rinse (CHX) for 60 days. Microbiological samples were evaluated by checkerboard DNA–DNA hybridization until 180 days post therapy. The adjunctive use of antibiotics plus CHX significantly reduced the mean proportions of red complex species from subgingival biofilm and saliva (p < 0.05). Furthermore, the analysis of all intraoral niches showed a significantly lower mean proportion of the red complex species in the same group. In conclusion, the concomitant use of antimicrobial chemical control (systemic and local) demonstrated a beneficial effect on the composition of the oral microbiota.
AbstractList The effect of systemic antibiotics on the microbial profile of extracrevicular sites after periodontal treatment is currently the subject of research. This study evaluated the microbiological effects on different oral cavity sites of scaling and root planing (SRP) combined with antimicrobial chemical control in the treatment of periodontitis. Sixty subjects were randomly assigned to receive SRP alone or combined with metronidazole (MTZ) + amoxicillin (AMX) for 14 days, with or without chlorhexidine mouth rinse (CHX) for 60 days. Microbiological samples were evaluated by checkerboard DNA–DNA hybridization until 180 days post therapy. The adjunctive use of antibiotics plus CHX significantly reduced the mean proportions of red complex species from subgingival biofilm and saliva (p < 0.05). Furthermore, the analysis of all intraoral niches showed a significantly lower mean proportion of the red complex species in the same group. In conclusion, the concomitant use of antimicrobial chemical control (systemic and local) demonstrated a beneficial effect on the composition of the oral microbiota.
The effect of systemic antibiotics on the microbial profile of extracrevicular sites after periodontal treatment is currently the subject of research. This study evaluated the microbiological effects on different oral cavity sites of scaling and root planing (SRP) combined with antimicrobial chemical control in the treatment of periodontitis. Sixty subjects were randomly assigned to receive SRP alone or combined with metronidazole (MTZ) + amoxicillin (AMX) for 14 days, with or without chlorhexidine mouth rinse (CHX) for 60 days. Microbiological samples were evaluated by checkerboard DNA-DNA hybridization until 180 days post therapy. The adjunctive use of antibiotics plus CHX significantly reduced the mean proportions of red complex species from subgingival biofilm and saliva (p < 0.05). Furthermore, the analysis of all intraoral niches showed a significantly lower mean proportion of the red complex species in the same group. In conclusion, the concomitant use of antimicrobial chemical control (systemic and local) demonstrated a beneficial effect on the composition of the oral microbiota.The effect of systemic antibiotics on the microbial profile of extracrevicular sites after periodontal treatment is currently the subject of research. This study evaluated the microbiological effects on different oral cavity sites of scaling and root planing (SRP) combined with antimicrobial chemical control in the treatment of periodontitis. Sixty subjects were randomly assigned to receive SRP alone or combined with metronidazole (MTZ) + amoxicillin (AMX) for 14 days, with or without chlorhexidine mouth rinse (CHX) for 60 days. Microbiological samples were evaluated by checkerboard DNA-DNA hybridization until 180 days post therapy. The adjunctive use of antibiotics plus CHX significantly reduced the mean proportions of red complex species from subgingival biofilm and saliva (p < 0.05). Furthermore, the analysis of all intraoral niches showed a significantly lower mean proportion of the red complex species in the same group. In conclusion, the concomitant use of antimicrobial chemical control (systemic and local) demonstrated a beneficial effect on the composition of the oral microbiota.
The effect of systemic antibiotics on the microbial profile of extracrevicular sites after periodontal treatment is currently the subject of research. This study evaluated the microbiological effects on different oral cavity sites of scaling and root planing (SRP) combined with antimicrobial chemical control in the treatment of periodontitis. Sixty subjects were randomly assigned to receive SRP alone or combined with metronidazole (MTZ) + amoxicillin (AMX) for 14 days, with or without chlorhexidine mouth rinse (CHX) for 60 days. Microbiological samples were evaluated by checkerboard DNA–DNA hybridization until 180 days post therapy. The adjunctive use of antibiotics plus CHX significantly reduced the mean proportions of red complex species from subgingival biofilm and saliva ( p < 0.05). Furthermore, the analysis of all intraoral niches showed a significantly lower mean proportion of the red complex species in the same group. In conclusion, the concomitant use of antimicrobial chemical control (systemic and local) demonstrated a beneficial effect on the composition of the oral microbiota.
The effect of systemic antibiotics on the microbial profile of extracrevicular sites after periodontal treatment is currently the subject of research. This study evaluated the microbiological effects on different oral cavity sites of scaling and root planing (SRP) combined with antimicrobial chemical control in the treatment of periodontitis. Sixty subjects were randomly assigned to receive SRP alone or combined with metronidazole (MTZ) + amoxicillin (AMX) for 14 days, with or without chlorhexidine mouth rinse (CHX) for 60 days. Microbiological samples were evaluated by checkerboard DNA-DNA hybridization until 180 days post therapy. The adjunctive use of antibiotics plus CHX significantly reduced the mean proportions of red complex species from subgingival biofilm and saliva ( < 0.05). Furthermore, the analysis of all intraoral niches showed a significantly lower mean proportion of the red complex species in the same group. In conclusion, the concomitant use of antimicrobial chemical control (systemic and local) demonstrated a beneficial effect on the composition of the oral microbiota.
Audience Academic
Author Esteves, Camila Machado
Figueiredo, Nathalia
de Miranda, Tamires Szeremeske
Mendes, Stella de Noronha Campos
Feres, Magda
Shibli, Jamil Awad
Mendes, Juliana Alethusa Velloso
Figueiredo, Luciene Cristina
AuthorAffiliation 1 Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07090-023, SP, Brazil jualethusa@hotmail.com (J.A.V.M.); mferes@ung.br (M.F.)
3 Department of Oral Medicine, Infection, and Immunity, Division of Periodontology, Harvard School of Dental Medicine, Boston, MA 02115, USA
2 Department of Dentistry, Federal University of Piaui, Teresina 64049-550, PI, Brazil
AuthorAffiliation_xml – name: 2 Department of Dentistry, Federal University of Piaui, Teresina 64049-550, PI, Brazil
– name: 1 Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07090-023, SP, Brazil jualethusa@hotmail.com (J.A.V.M.); mferes@ung.br (M.F.)
– name: 3 Department of Oral Medicine, Infection, and Immunity, Division of Periodontology, Harvard School of Dental Medicine, Boston, MA 02115, USA
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CitedBy_id crossref_primary_10_3390_jcm12124137
crossref_primary_10_2174_0109298673265862231020051338
crossref_primary_10_3390_ijms25137217
crossref_primary_10_1186_s12903_024_04660_5
crossref_primary_10_1186_s40168_024_01945_3
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Issue 5
Keywords saliva
tongue
antibacterial agents
metronidazole
periodontal diseases
antibiotics
biofilms
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Snippet The effect of systemic antibiotics on the microbial profile of extracrevicular sites after periodontal treatment is currently the subject of research. This...
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StartPage 847
SubjectTerms Amoxicillin
Analysis
antibacterial agents
Antibiotics
Antiinfectives and antibacterials
Bacteria
Biofilms
Chemical control
Chlorhexidine
Deoxyribonucleic acid
DNA
Hybridization
Metronidazole
Microbiology
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Mouth
Oral cavity
Pathogens
periodontal diseases
Periodontitis
Planing
Saliva
Tongue
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Title Systemic Antibiotics and Chlorhexidine Associated with Periodontal Therapy: Microbiological Effect on Intraoral Surfaces and Saliva
URI https://www.ncbi.nlm.nih.gov/pubmed/37237750
https://www.proquest.com/docview/2819262655
https://www.proquest.com/docview/2820019323
https://pubmed.ncbi.nlm.nih.gov/PMC10215836
https://doaj.org/article/9024a6c4224847c09da4d7c1f1fb3393
Volume 12
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