Comprehensive analysis and experimental verification reveal the molecular characteristics of EGLN3 in pan-cancer and its relationship with the proliferation and apoptosis of lung cancer

• Published in: Heliyon Vol. 10; no. 12; p. e33206
• Main Authors: Shi, Yuan-Xiang, Dai, Peng-Hui, Chen, Tao, Yan, Jian-Hua
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 30.06.2024; Elsevier
• Subjects: apoptosis; Cell apoptosis; cell proliferation; cytosol; EGLN3; family; fibroblasts; flow cytometry; fluorescent antibody technique; gene expression; Hypoxia; immunotherapy; lung neoplasms; macrophages; neoplasm cells; neoplasm progression; oncogenes; sequence analysis; Single-cell RNA sequencing; Tumor microenvironment; Hypoxia; EGLN3; Tumor microenvironment; Single-cell RNA sequencing; Cell apoptosis

Egl-9 family hypoxia-inducible factor 3 (EGLN3) is involved in the regulation of tumor microenvironment and tumor progression. However, its biological function and clinical significance in various cancers remain unclear. RNA-seq, immunofluorescence, and single-cell sequencing were used to investigat...