Precision Dosing of Meropenem in Adults with Normal Renal Function: Insights from a Population Pharmacokinetic and Monte Carlo Simulation Study

• Published in: Antibiotics (Basel) Vol. 13; no. 9; p. 849
• Main Authors: Kim, Yong Kyun, Kang, Gaeun, Zang, Dae Young, Lee, Dong Hwan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.09.2024; MDPI
• Subjects: Adults; Analysis; Antibiotics; Antimicrobial agents; Bacteria; Creatinine; Dosage; Dose-response relationship (Biochemistry); Drug dosages; Drug resistance; Effectiveness; Gram-negative bacteria; Health care; healthy; Meropenem; Minimum inhibitory concentration; Monte Carlo method; Monte Carlo simulation; noncompartmental analysis; normal renal function; Nosocomial infections; Patients; Pharmacokinetics; population pharmacokinetics; Population studies; Renal function; Therapeutic targets; South Korea; noncompartmental analysis; healthy; meropenem; normal renal function; adult; Monte Carlo simulation; population pharmacokinetics

This study aimed to develop a population pharmacokinetic (PK) model for meropenem in healthy adults and explore optimal dosing regimens for patients with normal renal function. PK samples were obtained from 12 healthy participants, which were analyzed using noncompartmental analysis and nonlinear mi...