APOE4 confers transcriptomic and functional alterations to primary mouse microglia - Machlovi, Saima I.; Neuner, Sarah M.; Hemmer, Brittany M.; Khan, Riana; Liu, Yiyuan; Huang, Min; Zhu, Jeffrey D.; Castellano, Joseph M.; Cai, Dongming; Marcora, Edoardo; Goate, Alison M. (Neurobiology of disease, 2022)
Keywords: Alleles; Alzheimer's disease; Animals; APOE genotype; Apolipoprotein E4 - genetics; Brain - metabolism; Cell Shape - physiology; eIF2 signaling; Genotype; Interferon signaling; Lipid accumulation; Lipid droplets; Mice; Microglia; Microglia - metabolism; Myelin; Neurons - metabolism; Phagocytosis; Phagocytosis - physiology; Transcriptome; Translation inhibition; TNFα; GWAS; LOAD; DAP12; eIF2 signaling; TREM2; PERK; CXCL2; E3; LXRs; E4; Aβ; NBD; p-eIF2α; p-PERK; PLCG2; MBP; APOE; Alzheimer's disease; WT; GCN2; RRHO; AD; KO; Lipid droplets; Myelin; p-PKR; GSEA; ER; ECM; Microglia; EAJ; eIF2α; DAM; TYROBP; OAS1; Translation inhibition; PKR; Interferon signaling; Lipid accumulation; PKN1; Phagocytosis; TR; TLRs; APOE genotype