Evoked potentials reveal neural circuits engaged by human deep brain stimulation

• Published in: Brain stimulation Vol. 13; no. 6; pp. 1706 - 1718
• Main Authors: Schmidt, Stephen L., Brocker, David T., Swan, Brandon D., Turner, Dennis A., Grill, Warren M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2020; Elsevier
• Subjects: Aged; Basal Ganglia - physiology; DBS; Deep Brain Stimulation - methods; Evoked Potentials, Motor - physiology; Female; Globus pallidus; Globus Pallidus - physiology; Humans; Male; Middle Aged; Nerve Net - physiology; Parkinson Disease - physiopathology; Parkinson Disease - therapy; Parkinson’’s disease; Rest - physiology; Stereotaxic Techniques; Subthalamic nucleus; Subthalamic Nucleus - physiology; Globus pallidus; Subthalamic nucleus; DBS; Parkinson’’s disease
• ISSN: 1935-861X; 1876-4754; 1876-4754
• DOI: 10.1016/j.brs.2020.09.028

Deep brain stimulation (DBS) is an effective therapy for reducing the motor symptoms of Parkinson’s disease, but the mechanisms of action of DBS and neural correlates of symptoms remain unknown. To use the neural response to DBS to reveal connectivity of neural circuits and interactions between grou...