Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity - Chen, Wei-Hung; Hajduczki, Agnes; Martinez, Elizabeth J.; Bai, Hongjun; Matz, Hanover; Hill, Thomas M.; Lewitus, Eric; Chang, William C.; Dawit, Layla; Peterson, Caroline E.; Rees, Phyllis A.; Ajayi, Adelola B.; et al. (Nature communications, 2023)
Keywords: 101/47; 13/1; 60 APPLIED LIFE SCIENCES; 631/154/51/1568; 631/250/255/2514; 631/535/1266; 631/61/24; 64/110; 82/80; 9/10; Affinity; Animals; Antibodies; Antibodies, Neutralizing; Antibodies, Viral; antibody therapy; Antigens; applied immunology; Chimeras; COVID-19; COVID-19 - prevention & control; Epitopes; Ferritin; Ferritins - genetics; Humanities and Social Sciences; Immunization; Immunoglobulin Fc Fragments; Mice; Mice, Transgenic; multidisciplinary; Nanobodies; Nanoparticles; Neutralization; Pandemics; Receptors; SARS-CoV-2 - genetics; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Severe acute respiratory syndrome-related coronavirus; Sharks; Single-Domain Antibodies; Spike Glycoprotein, Coronavirus - genetics; Spike protein; Transgenic mice; Vaccine efficacy; Vaccines; Viral diseases; viral infection; x-ray crystallography