Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity - Hezaveh, Kebria; Shinde, Rahul S; Klötgen, Andreas; Halaby, Marie Jo; Lamorte, Sara; Ciudad, M. Teresa; Quevedo, Rene; Neufeld, Luke; Liu, Zhe Qi; Jin, Robbie; Grünwald, Barbara T; Foerster, Elisabeth G; et al. (Immunity (Cambridge, Mass.), 2022)
Keywords: Animals; aryl hydrocarbon receptor; Carcinoma, Pancreatic Ductal - immunology; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - mortality; Carcinoma, Pancreatic Ductal - pathology; CD8-Positive T-Lymphocytes - immunology; Humans; immune suppression; Immune Tolerance - immunology; immunotherapy; indoles; Indoles - immunology; Indoles - metabolism; Lymphocytes, Tumor-Infiltrating - immunology; macrophage; metabolism; Mice; microbiome; Microbiota - immunology; pancreatic cancer; Pancreatic Neoplasms - immunology; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - mortality; Pancreatic Neoplasms - pathology; Prognosis; Receptors, Aryl Hydrocarbon - antagonists & inhibitors; Receptors, Aryl Hydrocarbon - genetics; Receptors, Aryl Hydrocarbon - immunology; Receptors, Aryl Hydrocarbon - metabolism; T cells; Tryptophan - immunology; Tryptophan - metabolism; tumor microenvironment; Tumor Microenvironment - drug effects; Tumor Microenvironment - immunology; Tumor-Associated Macrophages - immunology; Tumor-Associated Macrophages - metabolism; indoles; pancreatic cancer; immunotherapy; macrophage; metabolism; tumor microenvironment; T cells; immune suppression; microbiome; aryl hydrocarbon receptor