Development and validation of a mathematical model of heart rate response to fluid perturbation

• Published in: Scientific reports Vol. 12; no. 1; pp. 21463 - 16
• Main Authors: Kanal, Varun, Pathmanathan, Pras, Hahn, Jin-Oh, Kramer, George, Scully, Christopher, Bighamian, Ramin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.12.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114/1305; 631/114/2397; Animals; BASIC BIOLOGICAL SCIENCES; Clinical trials; Datasets; Heart rate; Heart Rate - physiology; Hemorrhage; Humanities and Social Sciences; Humans; Mathematical models; Medical equipment; multidisciplinary; Patients; Performance assessment; Physiological responses; Physiology; Science; Science & Technology - Other Topics; Science (multidisciplinary); Sheep

Physiological closed-loop controlled (PCLC) medical devices monitor and automatically adjust the patient’s condition by using physiological variables as feedback, ideally with minimal human intervention to achieve the target levels set by a clinician. PCLC devices present a challenge when it comes t...