Low Accuracy of FIB-4 and NAFLD Fibrosis Scores for Screening for Liver Fibrosis in the Population

• Published in: Clinical gastroenterology and hepatology Vol. 20; no. 11; pp. 2567 - 2576.e6
• Main Authors: Graupera, Isabel, Thiele, Maja, Serra-Burriel, Miquel, Caballeria, Llorenç, Roulot, Dominique, Wong, Grace Lai-Hung, Fabrellas, Núria, Guha, Indra Neil, Arslanow, Anita, Expósito, Carmen, Hernández, Rosario, Aithal, Guruprasad Padur, Galle, Peter R., Pera, Guillem, Wong, Vincent Wai-Sun, Lammert, Frank, Ginès, Pere, Castera, Laurent, Krag, Aleksander
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2022
• Subjects: Adult; Aged; Alcoholic Liver Disease; Biopsy - adverse effects; Female; Fibrosis; Gastroenterology and Hepatology; Humans; Liver - pathology; Liver Cirrhosis - etiology; Liver Fibrosis; Male; Middle Aged; NITs; Non-alcoholic Fatty Liver Disease - complications; Nonalcoholic Fatty Liver Disease; Noninvasive Fibrosis Scores; Prevalence; Screening; Severity of Illness Index; Transient Elastography; NAFLD; HK; DK; ALT; FR; AUC; Liver Fibrosis; NPV; UK; ULN; PPV; Noninvasive Fibrosis Scores; NFS; BMI; Transient Elastography; LSM; ES; Screening; TE; Alcoholic Liver Disease; Nonalcoholic Fatty Liver Disease; NIT; ALD; FIB-4; NITs; positive predictive value; Fibrosis-4 test; Hong Kong; alanine aminotransferase; non-invasive tests; France; liver stiffness measurement; area under the receiving operating characteristics curve; body mass index; NAFLD fibrosis score; United Kingdom; Spain; upper limit of normal; Denmark; negative predictive value

Fibrosis-4 (FIB-4) and the nonalcoholic fatty liver disease fibrosis score (NFS) are the 2 most popular noninvasive blood-based serum tests proposed for widespread fibrosis screening. We therefore aimed to describe the accuracy of FIB-4 and NFS to detect elevated liver stiffness as an indicator of h...