Poor Diagnostic Efficacy of Noninvasive Tests for Advanced Fibrosis in Obese or Younger Than 60 Diabetic NAFLD patients

• Published in: Clinical gastroenterology and hepatology Vol. 21; no. 4; pp. 1013 - 1022.e6
• Main Authors: Ito, Takanori, Nguyen, Vy H., Tanaka, Taku, Park, Huiyul, Yeh, Ming-Lun, Kawanaka, Miwa, Arai, Taeang, Atsukawa, Masanori, Yoon, Eileen L., Tsai, Pei-Chien, Toyoda, Hidenori, Huang, Jee-Fu, Henry, Linda, Jun, Dae Won, Yu, Ming-Lung, Ishigami, Masatoshi, Nguyen, Mindie H., Cheung, Ramsey C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2023
• Subjects: Aged; Alanine Transaminase; Aspartate Aminotransferases; Biopsy; Diabetes Mellitus, Type 2 - complications; FIB-4 Index; Gastroenterology and Hepatology; Hepamet Fibrosis Score; Humans; Liver Cirrhosis - complications; Liver Cirrhosis - diagnosis; Liver Cirrhosis - pathology; NITs; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - diagnosis; Non-alcoholic Fatty Liver Disease - pathology; Nonalcoholic Fatty Liver Disease; Obesity - complications; Severity of Illness Index; T2DM; AST; NAFLD; CI; ALT; AUROC; Hepamet Fibrosis Score; NASH; FIB-4 Index; HFS; EASL; NPV; Nonalcoholic Fatty Liver Disease; PPV; AASLD; FIB-4; NFS; NITs; BMI; positive predictive value; noninvasive tests; nonalcoholic steatohepatitis; alanine transaminase; type 2 diabetes mellitus; American Association for the Study of Liver Disease; area under the receiver operating characteristic; European Association for the Study of the Liver; body mass index; Fibrosis-4; NAFLD fibrosis score; aspartate aminotransferase; confidence interval; negative predictive value

Serum-based noninvasive tests (NITs) have been widely used to assess liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). However, the diagnostic efficacy of NITs across ranges of age, body mass index (BMI), and presence of type 2 diabetes (T2DM) may vary and have not been well-...