Inhibitory effect of schisandrin on spontaneous contraction of isolated rat colon

• Published in: Phytomedicine (Stuttgart) Vol. 18; no. 11; pp. 998 - 1005
• Main Authors: Yang, Jiaming, Ip, Paul S.P., Yeung, John H.K., Che, Chun-Tao
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 15.08.2011; Urban & Fischer Verlag
• Subjects: Adrenergic Antagonists - pharmacology; Animals; Atropine - pharmacology; Benzyl Compounds - pharmacology; Colon, Ascending - drug effects; Colon, Ascending - surgery; Colonic smooth muscle; Cyclic GMP - metabolism; Cyclooctanes - pharmacology; Enteric nervous system; Enzyme Inhibitors - metabolism; Health aspects; Imidazoles - pharmacology; In Vitro Techniques; Lignans - pharmacology; Male; Marine toxins; Muscle Contraction - drug effects; Muscle Relaxation; Nitric oxide; Nitric Oxide - metabolism; Non-adrenergic non-cholinergic relaxation; Phentolamine - pharmacology; Physiological aspects; Plant Extracts - pharmacology; Polycyclic Compounds - pharmacology; Propranolol - pharmacology; Purinergic Antagonists - pharmacology; Pyridoxal Phosphate - analogs & derivatives; Pyridoxal Phosphate - pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Epoprostenol - antagonists & inhibitors; Schisandra; Schisandra - chemistry; Schisandra chinensis; Schisandrin; Tetrodotoxin - pharmacology; Xanthines - pharmacology; Hong Kong; United States; Enteric nervous system; Colonic smooth muscle; Schisandra chinensis; Nitric oxide; Schisandrin; Non-adrenergic non-cholinergic relaxation

This study examined the effect of schisandrin, one of the major lignans isolated from Schisandra chinensis, on spontaneous contraction in rat colon and its possible mechanisms. Schisandrin produced a concentration-dependent inhibition (EC 50 = 1.66 μM) on the colonic spontaneous contraction. The rel...