Genome-wide kinetics of DNA excision repair in relation to chromatin state and mutagenesis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 15; pp. E2124 - E2133
• Main Authors: Adar, Sheera, Hu, Jinchuan, Lieb, Jason D., Sancar, Aziz
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 12.04.2016; National Acad Sciences
• Series: PNAS Plus
• Subjects: Biological Sciences; Cancer; Carcinogenesis; Cell Line; Chromatin; Chromatin - genetics; Deoxyribonucleic acid; DNA; DNA Repair - genetics; Genome, Human - genetics; Genomes; Humans; Irradiation; Kinetics; Melanoma - genetics; Mutagenesis; Mutagenesis - genetics; PNAS Plus; Risk assessment; Sequence Analysis, DNA - methods; Ultraviolet radiation; Ultraviolet Rays - adverse effects; mutation; transcription; chromatin; DNA repair; DNA damage

We recently developed a high-resolution genome-wide assay for mapping DNA excision repair named eXcision Repair-sequencing (XR-seq) and have now used XR-seq to determine which regions of the genome are subject to repair very soon after UV exposure and which regions are repaired later. Over a time co...