Test-retest properties of [11C]PXT012253 as a positron emission tomography (PET) radiotracer in healthy human brain: PET imaging of mGlu4

• Published in: EJNMMI research Vol. 15; no. 1; pp. 71 - 10
• Main Authors: Stenkrona, Per, Arakawa, Ryosuke, Guo, Jiamei, Bang-Andersen, Benny, Nag, Sangram, Moein, Mohammad Mahdi, Jia, Zhisheng, Cselenyi, Zsolt, Halldin, Christer, Varrone, Andrea
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 14.06.2025; Springer Nature B.V; SpringerOpen
• Subjects: [11C]PXT012253; Brain; Brain research; Cardiac Imaging; Catheters; Dyskinesia; Ethics; Human brain; Imaging; Ligands; Medical imaging; Medicine; Medicine & Public Health; mGlu4; Nuclear Medicine; Oncology; Original Research; Orthopedics; Parkinson's disease; Positron emission; Positron emission tomography (PET); Radioactive tracers; Radiology; Schizophrenia; Stability analysis; Standard error; Test-retest; Thalamus; Tomography; Test-retest; C]PXT012253; mGlu4; Human brain; Positron emission tomography (PET); [; [11C]PXT012253

Background The metabotropic glutamate receptor 4 (mGlu4) has been proposed as a target for Parkinson’s disease to measure levodopa-induced dyskinesia. [ 11 C]PXT012253 is a PET radioligand for mGlu4 (3.4 nM), previously characterized in non-human primates. We aimed to determine the optimal method fo...