T cell engineering as therapy for cancer and HIV: our synthetic future

• Published in: Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 370; no. 1680; p. 20140374
• Main Authors: June, Carl H., Levine, Bruce L.
• Format: Journal Article
• Language: English
• Published: England The Royal Society 19.10.2015
• Subjects: Cancer; Cell Engineering - methods; Cell Engineering - trends; Genetic Engineering; HIV Infections - immunology; HIV Infections - therapy; Human immunodeficiency virus; Humans; Immunotherapy; Immunotherapy, Adoptive; Lymphocytes, Tumor-Infiltrating - immunology; Neoplasms - immunology; Neoplasms - therapy; Receptors, Antigen, T-Cell - genetics; Receptors, Antigen, T-Cell - immunology; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - immunology; Review; Synthetic Biology; T-Lymphocytes - immunology; synthetic biology; cancer; immunotherapy

It is now well established that the immune system can control and eliminate cancer cells. Adoptive T cell transfer has the potential to overcome the significant limitations associated with vaccine-based strategies in patients who are often immune compromised. Application of the emerging discipline o...