Structural and energetic determinants of adhesive binding specificity in type I cadherins - Vendome, Jeremie; Felsovalyi, Klara; Song, Hang; Yang, Zhongyu; Jin, Xiangshu; Brasch, Julia; Harrison, Oliver J.; Ahlsen, Goran; Bahna, Fabiana; Kaczynska, Anna; Katsamba, Phinikoula S.; Edmond, Darwin; et al. (Proceedings of the National Academy of Sciences - PNAS, 2014)
Keywords: Amino Acid Sequence; Animals; binding capacity; Binding sites; Binding, Competitive; Biological Sciences; cadherins; Cadherins - chemistry; Cadherins - genetics; Cadherins - metabolism; cell adhesion; Cell adhesion & migration; Crystallography; Crystallography, X-Ray; dimerization; Electron Spin Resonance Spectroscopy; Electrons; Evolution; HEK293 Cells; Heterogeneity; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Mice; Models, Molecular; Molecular Sequence Data; Molecular structure; Mutation; PNAS Plus; PNAS PLUS Significance Statements; Protein Binding; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins; Resonance; Sequence Homology, Amino Acid; Static Electricity; Xenopus; Xenopus Proteins - chemistry; Xenopus Proteins - genetics; Xenopus Proteins - metabolism; entropy contribution; protein family design; cadherin dimerization