Comparison of predicted and actual consequences of missense mutations - Miosge, Lisa A.; Field, Matthew A.; Sontani, Yovina; Cho, Vicky; Johnson, Simon; Palkova, Anna; Balakishnan, Bhavani; Liang, Rong; Zhang, Yafei; Lyon, Stephen; Beutler, Bruce; Whittle, Belinda; et al. (Proceedings of the National Academy of Sciences - PNAS, 2015)
Keywords: Animals; Biological Sciences; Codon; Comparative analysis; Computational Biology; Computer Simulation; Exome; Experiments; Genetic Variation; Genome; Genome, Human; Genomes; Genotype; Humans; Immune System; Immunologic Deficiency Syndromes - genetics; Mice; Mice, Inbred C57BL; Models, Genetic; Mutation; Mutation, Missense; Neoplasms - genetics; Phenotype; PNAS Plus; Predictions; Rodents; Software; Tumor Suppressor Protein p53 - genetics; de novo mutation; nearly neutral; cancer; immunodeficiency; evolution