Nuclear Long Noncoding RNAs: Key Regulators of Gene Expression

• Published in: Trends in genetics Vol. 34; no. 2; pp. 142 - 157
• Main Authors: Sun, Qinyu, Hao, Qinyu, Prasanth, Kannanganattu V.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2018
• Subjects: Animals; Cell Nucleus - genetics; Cell Nucleus - metabolism; Chromatin - chemistry; Chromatin - metabolism; Chromosomal Proteins, Non-Histone - genetics; Chromosomal Proteins, Non-Histone - metabolism; Humans; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Polycomb-Group Proteins - genetics; Polycomb-Group Proteins - metabolism; RNA Processing, Post-Transcriptional; RNA, Long Noncoding - classification; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription, Genetic; X Chromosome Inactivation

A significant portion of the human genome encodes genes that transcribe long nonprotein-coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched on the chromatin or localized to specific subnuclear compartments. Nuclear lncRNAs participate in several biological proce...