Impaired barrier function in patients with house dust mite–induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expression - Steelant, Brecht; Farré, Ricard; Wawrzyniak, Paulina; Belmans, Jochen; Dekimpe, Emily; Vanheel, Hanne; Van Gerven, Laura; Kortekaas Krohn, Inge; Bullens, Dominique M.A.; Ceuppens, Jan L.; Akdis, Cezmi A.; Boeckxstaens, Guy; et al. (Journal of allergy and clinical immunology, 2016)
Keywords: Adult; Allergic rhinitis; Allergies; Allergy and Immunology; Animals; Anti-Inflammatory Agents - therapeutic use; Asthma; Biomarkers - metabolism; Biopsy; Case-Control Studies; Cytokines; Dermatophagoides pteronyssinus; Dextrans - metabolism; epithelial permeability; epithelial resistance; Female; Fluorescein-5-isothiocyanate - analogs & derivatives; Fluorescein-5-isothiocyanate - metabolism; Fluticasone - therapeutic use; fluticasone propionate; Humans; IL-4; leak pathway; Male; Mice; Mice, Inbred C57BL; Middle Aged; Mucous membrane; Nasal Mucosa - immunology; Nasal Mucosa - metabolism; Occludin - metabolism; Permeability; Proteins; Pyroglyphidae - immunology; Real-Time Polymerase Chain Reaction; Rhinitis, Allergic, Perennial - drug therapy; Rhinitis, Allergic, Perennial - immunology; Rhinitis, Allergic, Perennial - metabolism; tight junctions; Tight Junctions - metabolism; Zonula Occludens-1 Protein - metabolism; TER; epithelial resistance; IL-4; epithelial permeability; FP; NEC; INS; HDM; AR; ZO; Allergic rhinitis; TJ; fluticasone propionate; FD4; tight junctions; RT-qPCR; leak pathway; ALI; Fluorescein isothiocyanate–dextran 4 kDa; Zonula occludens; Air-liquid interface; House dust mite; Intranasal steroid; Real-time quantitative PCR; Tight junction; Nasal epithelial cell; Transepithelial resistance