Targeting histone deacetylase SIRT1 selectively eradicates EGFR TKI-resistant cancer stem cells via regulation of mitochondrial oxidative phosphorylation in lung adenocarcinoma

• Published in: Neoplasia (New York, N.Y.) Vol. 22; no. 1; pp. 33 - 46
• Main Authors: Sun, Jiangtao, Li, Guifang, Liu, Yiwen, Ma, Mingyang, Song, Kaifang, Li, Huaxu, Zhu, Daxing, Tang, XiaoJun, Kong, Jinyu, Yuan, Xiang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2020; Neoplasia Press; Elsevier
• Subjects: Original article; TKI; mtOXPHOS; LAD; IC50; CSCs

Lung adenocarcinoma (LAD) is a human malignancy successfully treated with the tyrosine kinase inhibitor (TKI) gefitinib; however, the enrichment of therapy resistant cancer stem cells (CSCs) in such patients is assumed to be a source of treatment failure. Evaluation of LAD cell populations treated w...