Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane

• Published in: Nature (London) Vol. 418; no. 6901; pp. 988 - 994
• Main Authors: Mellman, Ira, Chow, Amy, Toomre, Derek, Garrett, Wendy
• Format: Journal Article
• Language: English
• Published: London Nature Publishing 29.08.2002; Nature Publishing Group
• Subjects: Animals; Antigen Presentation; Antigens, CD - analysis; Biological and medical sciences; Cell Differentiation; Cell Membrane - metabolism; Cells, Cultured; Cellular biology; Dendritic Cells - cytology; Dendritic Cells - immunology; Dendritic Cells - metabolism; Endocytosis; Endosomes - metabolism; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Histocompatibility Antigens Class II - metabolism; Immunobiology; Life cycles; Lymphocytes; Lysosomal Membrane Proteins; Lysosomes - metabolism; Membrane Glycoproteins - analysis; Mice; Mice, Inbred C57BL; Microscopy, Video; Monocytes, macrophages; Myeloid cells: ontogeny, maturation, markers, receptors; Peptides; Plasma; Protein Transport; Stem Cells - cytology; Stem Cells - immunology; Stem Cells - metabolism; Ripening; Dendritic cell; Antigen presentation; Intracellular transport; Vertebrata; Mammalia; Mouse; Rodentia; Class II histocompatibility antigen; Lysosome; Plasma membrane

Central to the initiation of immune responses is recognition of peptide antigen by T lymphocytes. The cell biology of dendritic cells makes them ideally suited for the essential process of antigen presentation. Their life cycle includes several stages characterized by distinct functions and mechanis...