Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls

• Published in: Brain, behavior, and immunity Vol. 87; pp. 901 - 909
• Main Authors: Osimo, Emanuele F., Pillinger, Toby, Rodriguez, Irene Mateos, Khandaker, Golam M., Pariante, Carmine M., Howes, Oliver D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.07.2020; Elsevier
• Subjects: Biomarkers; CRP; Cytokine; Cytokines; Depression; Heterogeneity; Humans; Inflammation; Meta-analysis; Tumor Necrosis Factor-alpha; CRP; Heterogeneity; Depression; Inflammation; Cytokine; Meta-analysis

•Patients with depression show reduced variability in pro-inflammatory immune measures.•Patients with depression show increases in pro-inflammatory immune markers mean levels, and reductions in anti-inflammatory IL-4. The magnitude and variability of cytokine alterations in depression are not clear....