A Hox gene controls lateral line cell migration by regulating chemokine receptor expression downstream of Wnt signaling

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 42; pp. 16892 - 16897
• Main Authors: Breau, Marie A., Wilkinson, David G., Xu, Qiling
• Format: Journal Article
• Language: English
• Published: United States NATIONAL ACADEMY OF SCIENCES 15.10.2013; National Acad Sciences; National Academy of Sciences
• Subjects: Animal migration behavior; Animals; Biological Sciences; Cell adhesion & migration; Cell lines; Chemokine receptors; Chemokines; Danio rerio; Down regulation; Embryos; Gene expression; Gene expression regulation; Gene Expression Regulation, Developmental - physiology; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Neurons; Quantification; Receptors, CXCR - biosynthesis; Receptors, CXCR - genetics; Receptors, CXCR4 - biosynthesis; Receptors, CXCR4 - genetics; Siblings; Stem cells; Up-Regulation - physiology; Wnt Signaling Pathway - physiology; Zebrafish; Zebrafish - embryology; Zebrafish - genetics; Zebrafish Proteins - biosynthesis; Zebrafish Proteins - genetics; directional cell migration; Wnt-Hox-chemokine receptor pathway

The posterior lateral line primordium in zebrafish provides an amenable model to study mechanisms of collective cell migration. The directed migration of the cell cluster along the path of Sdf1a chemokine requires two receptors, Cxcr4b and Cxcr7b, which are expressed in the leading and trailing part...