A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA

• Published in: Nature communications Vol. 9; no. 1; pp. 2669 - 15
• Main Authors: Bangaru, Sandhya, Zhang, Heng, Gilchuk, Iuliia M., Voss, Thomas G., Irving, Ryan P., Gilchuk, Pavlo, Matta, Pranathi, Zhu, Xueyong, Lang, Shanshan, Nieusma, Travis, Richt, Juergen A., Albrecht, Randy A., Vanderven, Hillary A., Bombardi, Robin, Kent, Stephen J., Ward, Andrew B., Wilson, Ian A., Crowe, James E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.07.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/106; 13/109; 13/31; 14/1; 14/28; 45; 59; 631/250/2152/2153/1291; 631/326/596/1578; 64; Animals; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - administration & dosage; Antibodies, Neutralizing - immunology; Antibodies, Viral - administration & dosage; Antibodies, Viral - immunology; Antibody-Dependent Cell Cytotoxicity - drug effects; Antibody-Dependent Cell Cytotoxicity - immunology; Antigenic drift; Antigens; Cross Reactions - immunology; Crystal structure; Cytotoxicity; Egress; Electron microscopy; Epitopes; Epitopes - chemistry; Epitopes - immunology; Esterase; Hemagglutinin Glycoproteins, Influenza Virus - chemistry; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Hemagglutinins; Humanities and Social Sciences; Humans; Influenza; Influenza A; Influenza A Virus, H3N2 Subtype - drug effects; Influenza A Virus, H3N2 Subtype - immunology; Influenza A Virus, H3N2 Subtype - physiology; Influenza, Human - immunology; Influenza, Human - prevention & control; Influenza, Human - virology; Monoclonal antibodies; multidisciplinary; Neutralization; Neutralizing; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - veterinary; Orthomyxoviridae Infections - virology; Science; Science (multidisciplinary); Swine; Swine Diseases - immunology; Swine Diseases - prevention & control; Swine Diseases - virology; Toxicity; Vaccines; Viruses

The high rate of antigenic drift in seasonal influenza viruses necessitates frequent changes in vaccine composition. Recent seasonal H3 vaccines do not protect against swine-origin H3N2 variant (H3N2v) strains that recently have caused severe human infections. Here, we report a human V H 1-69 gene-e...