Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination

• Published in: Cell reports (Cambridge) Vol. 29; no. 4; pp. 904 - 919.e9
• Main Authors: Tripathi, Ajai, Volsko, Christina, Garcia, Jessie P., Agirre, Eneritz, Allan, Kevin C., Tesar, Paul J., Trapp, Bruce D., Castelo-Branco, Goncalo, Sim, Fraser J., Dutta, Ranjan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.10.2019; Elsevier
• Subjects: miRNA; multiple sclerosis; oligodendrocyte progenitor cells; remyelination; miRNA; oligodendrocyte progenitor cells; multiple sclerosis; remyelination

Remyelination requires the generation of new oligodendrocytes (OLs), which are derived from oligodendrocyte progenitor cells (OPCs). Maturation of OPCs into OLs is a multi-step process. Here, we describe a microRNA expressed by OLs, miR-27a, as a regulator of OL development and survival. Increased l...