Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 38; pp. 15101 - 15108
• Main Authors: Stylianopoulos, Triantafyllos, Martin, John D., Chauhan, Vikash P., Jain, Saloni R., Diop-Frimpong, Benjamin, Bardeesy, Nabeel, Smith, Barbara L., Ferrone, Cristina R., Hornicek, Francis J., Boucher, Yves, Munn, Lance L., Jain, Rakesh K.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 18.09.2012; National Acad Sciences
• Series: Inaugural Article
• Subjects: Adenocarcinoma - pathology; Animals; Biological Sciences; blood; blood flow; Blood vessels; Blood Vessels - pathology; Cancer; Cell growth; Cells; Collagen; Collagen - chemistry; Collagens; Compressive stress; drugs; Female; fibroblasts; Fibroblasts - pathology; Human subjects; Humans; hyaluronic acid; Hyaluronic Acid - chemistry; Hypoxia; immunotherapy; Immunotherapy - methods; inflammation; Mathematical models; Mechanical stress; metastasis; Mice; Mice, SCID; Models, Theoretical; neoplasm cells; Neoplasm Transplantation; neoplasms; Neoplasms - pathology; Pancreatic Ducts - pathology; Pancreatic Neoplasms - pathology; Perfusion; Physical Sciences; Solids; Stress; Stress, Mechanical; Stromal Cells - cytology; Tensile stress; Tumors

The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress intratumoral lymphatic and blood vessels. Compression of lymphatic vessels ele...