Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors - Stylianopoulos, Triantafyllos; Martin, John D.; Chauhan, Vikash P.; Jain, Saloni R.; Diop-Frimpong, Benjamin; Bardeesy, Nabeel; Smith, Barbara L.; Ferrone, Cristina R.; Hornicek, Francis J.; Boucher, Yves; Munn, Lance L.; Jain, Rakesh K. (Proceedings of the National Academy of Sciences - PNAS, 2012)
Keywords: Adenocarcinoma - pathology; Animals; Biological Sciences; blood; blood flow; Blood vessels; Blood Vessels - pathology; Cancer; Cell growth; Cells; Collagen; Collagen - chemistry; Collagens; Compressive stress; drugs; Female; fibroblasts; Fibroblasts - pathology; Human subjects; Humans; hyaluronic acid; Hyaluronic Acid - chemistry; Hypoxia; immunotherapy; Immunotherapy - methods; inflammation; Mathematical models; Mechanical stress; metastasis; Mice; Mice, SCID; Models, Theoretical; neoplasm cells; Neoplasm Transplantation; neoplasms; Neoplasms - pathology; Pancreatic Ducts - pathology; Pancreatic Neoplasms - pathology; Perfusion; Physical Sciences; Solids; Stress; Stress, Mechanical; Stromal Cells - cytology; Tensile stress; Tumors