Urine metabolite analysis as a function of deoxynivalenol exposure: an NMR-based metabolomics investigation
Deoxynivalenol (DON) is a toxic fungal metabolite that frequently contaminates cereal crops including wheat, maize and barley. Despite knowledge of frequent exposure through diet, our understanding of the potential consequences of human exposure remains limited, in part due to the lack of validated...
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Published in | Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Vol. 27; no. 2; pp. 255 - 261 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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01.02.2010
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Abstract | Deoxynivalenol (DON) is a toxic fungal metabolite that frequently contaminates cereal crops including wheat, maize and barley. Despite knowledge of frequent exposure through diet, our understanding of the potential consequences of human exposure remains limited, in part due to the lack of validated exposure biomarkers. In this study, we interrogated the urinary metabolome using nuclear magnetic resonance (NMR) spectroscopy to compare individuals with known low and high DON exposure through consumption of their normal diet. Urine samples from 22 adults from the UK (seven males, 15 females; age range = 21-59 years) had previously determined urinary DON levels using an established liquid chromatography-mass spectrometry (LC-MS) assay. Urine samples were subsequently analysed using an NMR-based metabolomics approach coupled with multivariate statistical analysis. Metabolic profiling suggested that hippurate levels could be used to distinguish between groups with low (3.6 ng DON mg
−1
creatinine: 95% CI = 2.6, 5.0 ng mg
−1
) and high (11.1 ng mg
−1
: 95% CI = 8.1, 15.5 ng mg
−1
) DON exposure, with the concentration of hippurate being significantly (1.5 times) higher for people with high DON exposure than for those with low DON exposure (p = 0.047). This, to our knowledge, is the first report of a metabolomics-derived biomarker of DON exposure in humans. |
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AbstractList | Deoxynivalenol (DON) is a toxic fungal metabolite that frequently contaminates cereal crops including wheat, maize and barley. Despite knowledge of frequent exposure through diet, our understanding of the potential consequences of human exposure remains limited, in part due to the lack of validated exposure biomarkers. In this study, we interrogated the urinary metabolome using nuclear magnetic resonance (NMR) spectroscopy to compare individuals with known low and high DON exposure through consumption of their normal diet. Urine samples from 22 adults from the UK (seven males, 15 females; age range = 21-59 years) had previously determined urinary DON levels using an established liquid chromatography-mass spectrometry (LC-MS) assay. Urine samples were subsequently analysed using an NMR-based metabolomics approach coupled with multivariate statistical analysis. Metabolic profiling suggested that hippurate levels could be used to distinguish between groups with low (3.6 ng DON mg
−1
creatinine: 95% CI = 2.6, 5.0 ng mg
−1
) and high (11.1 ng mg
−1
: 95% CI = 8.1, 15.5 ng mg
−1
) DON exposure, with the concentration of hippurate being significantly (1.5 times) higher for people with high DON exposure than for those with low DON exposure (p = 0.047). This, to our knowledge, is the first report of a metabolomics-derived biomarker of DON exposure in humans. Deoxynivalenol (DON) is a toxic fungal metabolite that frequently contaminates cereal crops including wheat, maize and barley. Despite knowledge of frequent exposure through diet, our understanding of the potential consequences of human exposure remains limited, in part due to the lack of validated exposure biomarkers. In this study, we interrogated the urinary metabolome using nuclear magnetic resonance (NMR) spectroscopy to compare individuals with known low and high DON exposure through consumption of their normal diet. Urine samples from 22 adults from the UK (seven males, 15 females; age range = 21-59 years) had previously determined urinary DON levels using an established liquid chromatography-mass spectrometry (LC-MS) assay. Urine samples were subsequently analysed using an NMR-based metabolomics approach coupled with multivariate statistical analysis. Metabolic profiling suggested that hippurate levels could be used to distinguish between groups with low (3.6 ng DON mg-1 creatinine: 95% CI = 2.6, 5.0 ng mg-1) and high (11.1 ng mg-1: 95% CI = 8.1, 15.5 ng mg-1) DON exposure, with the concentration of hippurate being significantly (1.5 times) higher for people with high DON exposure than for those with low DON exposure (p = 0.047). This, to our knowledge, is the first report of a metabolomics-derived biomarker of DON exposure in humans. Deoxynivalenol (DON) is a toxic fungal metabolite that frequently contaminates cereal crops including wheat, maize and barley. Despite knowledge of frequent exposure through diet, our understanding of the potential consequences of human exposure remains limited, in part due to the lack of validated exposure biomarkers. In this study, we interrogated the urinary metabolome using nuclear magnetic resonance (NMR) spectroscopy to compare individuals with known low and high DON exposure through consumption of their normal diet. Urine samples from 22 adults from the UK (seven males, 15 females; age range = 21-59 years) had previously determined urinary DON levels using an established liquid chromatography-mass spectrometry (LC-MS) assay. Urine samples were subsequently analysed using an NMR-based metabolomics approach coupled with multivariate statistical analysis. Metabolic profiling suggested that hippurate levels could be used to distinguish between groups with low (3.6 ng DON mg... creatinine: 95% CI = 2.6, 5.0 ng mg...) and high (11.1 ng mg...: 95% CI = 8.1, 15.5 ng mg...) DON exposure, with the concentration of hippurate being significantly (1.5 times) higher for people with high DON exposure than for those with low DON exposure (p = 0.047). This, to our knowledge, is the first report of a metabolomics-derived biomarker of DON exposure in humans. (ProQuest: ... denotes formulae/symbols omitted.) |
Author | Turner, E. Turner, P.C. Hopton, R.P. Fisher, J. Burley, V.J. |
Author_xml | – sequence: 1 givenname: R.P. surname: Hopton fullname: Hopton, R.P. organization: Molecular Epidemiology Unit and Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds – sequence: 2 givenname: E. surname: Turner fullname: Turner, E. organization: School of Chemistry, University of Leeds – sequence: 3 givenname: V.J. surname: Burley fullname: Burley, V.J. organization: Molecular Epidemiology Unit and Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds – sequence: 4 givenname: P.C. surname: Turner fullname: Turner, P.C. organization: Molecular Epidemiology Unit and Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds – sequence: 5 givenname: J. surname: Fisher fullname: Fisher, J. email: J.Fisher@chem.leeds.ac.uk organization: School of Chemistry, University of Leeds |
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Keywords | Urine Biological fluid Bakery product Metabolite Mycotoxin Vomitoxin analysis - nuclear magnetic resonance (NMR) NMR spectrometry cereals and grain Trichothecene Beer Bread Fungi Alcoholic beverage Toxin mycotoxins - trichothecenes exposure Cereal product Analysis Fusarium Cereal Fungi Imperfecti mycotoxins - Fusarium |
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Snippet | Deoxynivalenol (DON) is a toxic fungal metabolite that frequently contaminates cereal crops including wheat, maize and barley. Despite knowledge of frequent... |
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SubjectTerms | Adult analysis - nuclear magnetic resonance (NMR) beer Beers Biological and medical sciences Biomarkers bread cereals and grain Crops Environmental Exposure exposure Female Fermented food industries Food contamination & poisoning Food industries Food toxicology Fundamental and applied biological sciences. Psychology Fungi Hordeum vulgare Human exposure Humans Magnetic Resonance Spectroscopy - methods Male Metabolomics Middle Aged Multivariate analysis mycotoxins - Fusarium mycotoxins - trichothecenes Mycotoxins - urine NMR Nuclear magnetic resonance Trichothecenes - urine Triticum aestivum Zea mays |
Title | Urine metabolite analysis as a function of deoxynivalenol exposure: an NMR-based metabolomics investigation |
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